Organ toxicity of selected chemicals.
trolytes, glucose, and amino acids is impaired. Feedback mechanisms decrease glomerular filtration and thus prevent delivery of large volumes of water to nephron segments. Urine output may be increased, decreased, or unchanged. Markers of glomerular filtration, blood urea nitrogen (BUN) and creatinine, are increased only if filtration falls by 80%. The urine may contain glucose and protein, including proteinaceous casts formed in the nephron of tubular debris.
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