Figure 603

The role of the hypothalamic-pituitary axis in the regulation of adrenocortical hormone synthesis and release. The major physiological stimulus for the synthesis and release of glucocorticoids is corticotropin (ACTH) secreted from the anterior pituitary gland. ACTH secretion is regulated by corti-cotropin-releasing factor (CRF) from the paraventricular region of the hypothalamus. The release of CRF in turn is controlled by glucocorticoid levels and by input from the hippocampus. Both endogenous and exogenous glucocorticoids feed back negatively to regulate the secretion of ACTH and CRF. Glucocorticoid and mineralocorticoid receptors (GR and MR) in the hippocampus also negatively modulate CRF synthesis and release.

Blood Pressure Health

Blood Pressure Health

Your heart pumps blood throughout your body using a network of tubing called arteries and capillaries which return the blood back to your heart via your veins. Blood pressure is the force of the blood pushing against the walls of your arteries as your heart beats.Learn more...

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