Figure 584

Theoretical mechanism of transcription disruption by oligomers.

gene also is feasible. This strategy, however, requires extremely efficient and specific homologous recombination events in the target cell population. Such strategies have allowed for the development of knockout animals, but to date have not been practical for human somatic cell gene therapy. Ongoing investigations are exploring the feasibility of inducible vectors, use of the cre-lox system, or cell type specific promoters to optimize gene expression in target cells.

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