Elimination of a hypothetical drug with a half-life of 5 hours. The drug concentration decreases by 50% every 5 hours (i.e., t1/2 = 5 hours). The slope of the line is the elimination rate (kj.

the clinician must wait five half-lives (in this case, 25 hours) before administering the second drug. It will also require five half-lives for a drug to reach steady state (see Pharmacokinetics of Single Versus Multiple Dosing, later in the chapter), again, independent of the duration of the half-life. Steady state is when the amount of drug entering the body is equal to the amount of drug being eliminated in a given period. Finally, it is a rule of thumb (though certainly not absolute) that drugs are generally dosed every half-life (with allowance for rounding to convenient intervals). Thus, the concept of half-life has considerable importance for determining dosing frequency or adjusting doses in a patient.

How To Bolster Your Immune System

How To Bolster Your Immune System

All Natural Immune Boosters Proven To Fight Infection, Disease And More. Discover A Natural, Safe Effective Way To Boost Your Immune System Using Ingredients From Your Kitchen Cupboard. The only common sense, no holds barred guide to hit the market today no gimmicks, no pills, just old fashioned common sense remedies to cure colds, influenza, viral infections and more.

Get My Free Audio Book

Post a comment