Concentration-time profile for a hypothetical drug administered intravenously. Following intravenous dosing of a drug, blood concentrations of the drug reach a maximum almost immediately. Y-axis is logarithmic scale.

centration-time profile. Cmax is defined as the maximum concentration achieved in the blood. In Figure 5.2, Cmax can be estimated to be approximately 225 ^g/mL. The other pharmacokinetic parameter that can be easily estimated from a concentration-time profile is Tmax, or the time needed to reach maximum concentration. In Figure 5.2, the Tmax is estimated by visual inspection to be approximately 2 hours. The same drug in a formulation that permits a faster rate of absorption would have a shorter Tmax and generally a higher Cmax than the formulation with slower absorptive properties. Likewise, all other things being equal, a drug with a slower elimi

The Prevention and Treatment of Headaches

The Prevention and Treatment of Headaches

Are Constant Headaches Making Your Life Stressful? Discover Proven Methods For Eliminating Even The Most Powerful Of Headaches, It’s Easier Than You Think… Stop Chronic Migraine Pain and Tension Headaches From Destroying Your Life… Proven steps anyone can take to overcome even the worst chronic head pain…

Get My Free Audio Book

Post a comment