Concentration-time profile for a hypothetical drug administered intravenously. Following intravenous dosing of a drug, blood concentrations of the drug reach a maximum almost immediately. Y-axis is logarithmic scale.

centration-time profile. Cmax is defined as the maximum concentration achieved in the blood. In Figure 5.2, Cmax can be estimated to be approximately 225 ^g/mL. The other pharmacokinetic parameter that can be easily estimated from a concentration-time profile is Tmax, or the time needed to reach maximum concentration. In Figure 5.2, the Tmax is estimated by visual inspection to be approximately 2 hours. The same drug in a formulation that permits a faster rate of absorption would have a shorter Tmax and generally a higher Cmax than the formulation with slower absorptive properties. Likewise, all other things being equal, a drug with a slower elimi

Coping with Asthma

Coping with Asthma

If you suffer with asthma, you will no doubt be familiar with the uncomfortable sensations as your bronchial tubes begin to narrow and your muscles around them start to tighten. A sticky mucus known as phlegm begins to produce and increase within your bronchial tubes and you begin to wheeze, cough and struggle to breathe.

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