Figure 501

Replicative cycles of representative DNA and RNA viruses. A. Replicative cycle of a herpesvirus, an example of a DNA virus. 1. Attachment. 2. Membrane fusion. 3. Release of viral DNA through nuclear pores. 4. Transcription of viral mRNA. 5. Synthesis of viral proteins by host cell's ribosomes. 6. Replication of viral DNA by viral polymerases. 7. Assembly of virus particles. 8. Budding and release of progeny virus. B. Replicative cycle of an influenza virus, an example of an RNA virus. 1. Attachment. 2. Endocytosis. 3. Influx of H+ through M2 protein. 4. Fusion of the viral envelope with the endosomes membrane, dissociation of the RNP complex, and entry of viral RNA into the nucleus. 5. Synthesis of viral mRNA by viral RNA polymerase. 6. Translation of viral mRNA by host cell's ribosomes. 7. Replication of viral RNA, using viral RNA polymerase, via cRNA replicative form. 8. Assembly of virus particles. and 9. Budding and release of progeny virus.

by the host cell's cytoplasm, forming a vacuole. Next, the protein coat dissociates and releases the viral genome, usually into the host cell's nucleus.

Following the release of its genome, the virus synthesizes nucleic acids and proteins in sequence. In DNA viruses, the first genes to be transcribed are the immediate-early genes. These genes code for regulatory proteins that in turn initiate the transcription of the early genes responsible for viral genome replication. After the viral DNA is replicated, the late genes are transcribed and translated, producing proteins required for the assembly of the new virions. RNA viruses have several major strategies for genome replication and protein expression. Certain RNA viruses contain enzymes that synthesize messenger RNA (mRNA) using their RNA as a template; others use their own RNA as mRNA. The retroviruses use viral reverse transcriptase enzymes to produce DNA using viral RNA as a template. The newly synthesized DNA integrates into the host genome and is transcribed into mRNA and genomic RNA for progeny virions.

Following their production, the viral components are assembled to form a mature virus particle. The viral genome is encapsulated by viral protein; in some cases (e.g. adenovirus, poliovirus), it is not encapsulated. In certain viruses, such as the poxviruses, multiple membranes surround the capsid. Release of the virus from the host cell may be rapid and produce cell lysis and death. A slower process resembling budding may allow the host cell to survive.

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