Influences on parietal cell acid secretion. The pathways by which secretagogues are believed to stimulate hydrogen ion production and secretion are shown. In addition, the sites of action (broken arrows) of various acid suppressive medications are shown. A, atropine; PGE, prostaglandin E; H, histamine; G, gastrin, Riand Rs, inhibitory and stimulatory receptor-binding sites; Giand Gs, inhibitory and stimulatory catalytic subunits; ATP, adenosine triphosphate; ATPase, adenosine triphosphatase. (Reprinted with permission from Wolfe MM and Soll AH. The physiology of gastric acid secretion. N Engl J Med 1988;319:1707.)
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If you suffer with asthma, you will no doubt be familiar with the uncomfortable sensations as your bronchial tubes begin to narrow and your muscles around them start to tighten. A sticky mucus known as phlegm begins to produce and increase within your bronchial tubes and you begin to wheeze, cough and struggle to breathe.