Figure 334

The actions of Li+ on postsynaptic receptor-mediated second-messenger signaling systems. Lithium can simultaneously alter the flow of synaptic information through several receptor-mediated systems by diminishing coupling between the receptor recognition site and its specific G proteins. This model explains the stabilizing actions of Li+ at both ends of the mood spectrum through a single action at the G-protein level. Attenuating actions of Li+ have been demonstrated through G-protein interactions at the p-adrenoceptor and the acetylcholine M1 muscarinic receptor systems of the CNS. A second action of Li+ as an inhibitor of inositol diphosphate (IP2) phosphatase may further attenuate the flow of synaptic information through the M1 muscarinic receptor by the eventual depletion of membrane phosphatidyl inositol-bis-phosphate (PIP2). IP3, inositol triphosphate; DAG, diacylglycerol; ATP adenosine triphosphate; cAMP cyclic adenosine monophosphate; 5'-AMP 5'-adenosine monophosphate; NE, norepinephrine; ACh, acetylcholine.

drugs (diuretics), medical conditions (diarrhea), or physical activities (those that induce sweating) that deplete the body of Na+.

The elimination rate of Li+ from the body is variable. It is quite rapid during the first 10 hours after ingestion, and this period accounts for about 40% of the total Li+ excretion. However, the remaining portion of the Li+ dose is excreted very slowly over 14 days. Because of this biphasic elimination rate, clinically useful serum Li+ concentrations are usually determined 12 hours after the last dose. This period assures a relatively accurate reflection of the Li+ concentration, since it is beyond the most variable portion (rapid elimination phase) of the Li+ elimination profile.

10 Ways To Fight Off Cancer

10 Ways To Fight Off Cancer

Learning About 10 Ways Fight Off Cancer Can Have Amazing Benefits For Your Life The Best Tips On How To Keep This Killer At Bay Discovering that you or a loved one has cancer can be utterly terrifying. All the same, once you comprehend the causes of cancer and learn how to reverse those causes, you or your loved one may have more than a fighting chance of beating out cancer.

Get My Free Ebook

Post a comment