Figure 282

Nicotinic ACh receptor (AChR) at the muscle end plate. A. The AChR is a pentameric complex made up of five subunits surrounding a central conducting channel. Embryonic AChR, containing the 7-subunit as shown, is a low-conducting channel. Adult AChR has instead an e-subunit and is a high-conducting channel. B. Cooperative binding of two ACh (ACh) molecules produces a conformational change that results in channel opening. C. The open channel allows Na+ and Ca++ to enter and K+ to exit simultaneously. The result is a net inflow of positive charge and a membrane depolarization.

Blood Pressure Health

Blood Pressure Health

Your heart pumps blood throughout your body using a network of tubing called arteries and capillaries which return the blood back to your heart via your veins. Blood pressure is the force of the blood pushing against the walls of your arteries as your heart beats.Learn more...

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