Sites where drugs may act to alter neurotransmission. The steps are depicted for a typical neurotransmitter (T). Some neurotransmitters do not follow this scheme. Site 1 is an action potential; site 2, synthesis of T from T'; site 3, storage of T in vesicles; site 4, release of T in response to the action potential; site 5, binding of T to receptor; site 6, intracellular response to action of T at site 5; site 7, reuptake of T across neuronal membrane; site 8, metabolism of T to an inactive metabolite, TM.
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