Partial summary of lipoprotein metabolism in humans. I to VII are sites of action of hypolipidemic drugs. I, stimulation of bile acid and/or cholesterol fecal excretion; II, stimulation of lipoprotein lipase activity; III, inhibition of VLDL production and secretion; IV, inhibition of cholesterol biosynthesis; V, stimulation of cholesterol secretion into bile fluid; VI, stimulation of cholesterol conversion to bile acids; VII, increased plasma clearance of LDL due either to increased LDL receptor activity or altered lipoprotein composition. CHOL, cholesterol; IDL, intermediate-density lipoprotein.
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