Partial summary of lipoprotein metabolism in humans. I to VII are sites of action of hypolipidemic drugs. I, stimulation of bile acid and/or cholesterol fecal excretion; II, stimulation of lipoprotein lipase activity; III, inhibition of VLDL production and secretion; IV, inhibition of cholesterol biosynthesis; V, stimulation of cholesterol secretion into bile fluid; VI, stimulation of cholesterol conversion to bile acids; VII, increased plasma clearance of LDL due either to increased LDL receptor activity or altered lipoprotein composition. CHOL, cholesterol; IDL, intermediate-density lipoprotein.
ported capacities of statins to inhibit proliferation of arterial wall smooth muscle cells and to improve endothelial cell functions may be due to inhibited protein isoprenylation in these cells secondary to HMG CoA reductase inhibition.
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