The fibrinolytic system in blood vessels showing the physiological mechanisms of activation of plasminogen on fibrin to cause fibrinolysis and the pathophysiological mechanism in the blood to cause fibrinogenolysis. The release of t-PA from vascular endothelium and the inhibitory effect of a2-antiplasmin on plasmin activity are depicted. PAI-1, plasminogen activator inhibitor-1; FDP fibrin degradation products; factor, coagulation factor. (Modified with permission from Wiman B and Hamsten A. The fibrinolytic enzyme system and its role in the etiology of thromboembolic disease. Semin Thromb Hemost 1990;16:207.)
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