Figure 221

Hemostatic mechanisms showing the relationships among the vascular, platelet, and coagulation phases. Action is denoted by broken arrows, transformation by solid arrows. Circled factors are those that require vitamin K for activity. Proteins C and S, which degrade factors Va and VIIIa and require vitamin K for activity, are not shown. This figure is a highly simplified summary; see supplemental reading for further details. PL, platelet phospholipid; HMWK, high molecular weight kininogen; PreK, prekallikrein; ADP adenosine diphosphate; vWF, Von Willebrand factor; TxA2, thromboxane A2. (Modified with permission from Wintrobe MM et al. Clinical Hematology (7th ed.). Philadelphia: Lea & Febiger, 1974:390, 422.)

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