Factors Affecting Rate Of Gastrointestinal Absorption

In addition to the lipid-water partition coefficient of drugs, local blood flow, and intestinal surface area, other factors may affect absorption from the gastrointestinal tract.

Gastric Emptying Time

The rate of gastric emptying markedly influences the rate at which drugs are absorbed, whether they are acids, bases, or neutral substances. In general, factors that accelerate gastric emptying time, thus permitting drugs to reach the large absorptive surface of the small intestine sooner, will increase drug absorption unless the drug is slow to dissolve. A list of physiological, pathological, and pharmacological factors that in fluence the rate of gastric emptying is provided in Table 3.1.

Intestinal Motility

Increased gastrointestinal motility may facilitate drug absorption by thoroughly mixing intestinal contents and thereby bringing the drug into more intimate contact with the mucosal surface. However, the opposite may also occur in that an increase in motility may reduce contact time in the upper portion of the intestine where most of drug absorption occurs. Conversely, a decrease in gastrointestinal motility may promote absorption by increasing contact time. Thus, the effect depends on the drug and change in motility. Serious intestinal diseases, particularly those associated with intestinal sloughing, can be expected to alter drug absorption dramatically.

Food

Absorption of most drugs from the gastrointestinal tract is reduced or delayed by the presence of food in the gut. Drugs such as the tetracyclines, which are highly ionized, can complex with Ca++ ions in membranes, food, or milk, leading to a reduction in their rate of absorption. For drugs that are ionized in the stomach and un-ionized in the intestine, overall absorption will be delayed by any factor that delays gastric emptying. Finally, increased splanchnic blood flow, as occurs during eating, will increase the rate of drug absorption.

Formulation Factors

The ability of solid drug forms to dissolve and the solubility of the individual drug in the highly acidic gastric juice must be considered. For example, although the anticoagulant dicumarol has a very high lipid-water partition coefficient, it precipitates at the low pH of gastric juice, and the rate of its absorption is

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Responses

  • Naomi
    What are the factors that affect the rate of dissolution?
    1 year ago
  • Serena Pugliesi
    How presence of food affect the rate of drug absorption in small intestine?
    12 months ago
  • SUSANNE
    What are the factors that affrct absorption from the gastrointestinal tract?
    11 months ago
  • Klaudia
    What are the main factors that affecing absorption coefficient haw and why?
    11 months ago
  • umberto napolitano
    How gi motiloty decrease absorption?
    10 months ago
  • robinia brown
    What are the factors that affect the abdorption of lipid from the intestinal tract?
    9 months ago
  • ren
    How worm affects small intestine absorption coefficient?
    8 months ago
  • degna
    How does intestinal motility affect drug absorption?
    7 months ago
  • Robinia
    Which factors affect gastric drug absoption?
    6 months ago
  • Manuela
    Can eating to slowly change the rate of absorption of a drug?
    5 months ago
  • frank
    How does motility in GI tract affects drug absorption?
    4 months ago
  • averardo
    How does meth affect intestinal motility?
    3 months ago
  • STEFAN
    How does gi function and drug absorption?
    3 months ago
  • hayley watson
    How does surface area of absorption sites affect absorption in gi tract?
    3 months ago
  • giacomo ricci
    Does gi bleed affect absorption of fluconazole?
    3 months ago
  • Sofia
    How does nacotics effect the GI tract?
    3 months ago
  • RUSSELL
    What effect does increased gastric emptying time have on medication absorption?
    2 months ago
  • niklas
    What are 3 factors which may affect the health of the gastrointestinal system?
    2 months ago
  • petra
    How does the parkisons affect GI tract?
    2 months ago
  • Haile
    How does gastrointestinal motility affect drug absorption?
    2 months ago
  • Roosa
    How does G.I.T mortility affect drug absorption?
    17 days ago

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