Histamine stimulates bronchiolar smooth muscle contraction through activation of Hj-receptors. A much smaller bronchodilatory response is evoked by stimulation of H2-receptors. Asthmatics are generally more sensitive to the bronchoconstrictor actions of histamine than are nonasthmatics.
Histamine is able to cause uterine contraction. Although the magnitude of this effect in humans is normally small, the large amounts of histamine released during anaphylactic reactions can initiate abortion in pregnant women. Histamine can also stimulate contraction of gastrointestinal smooth muscle, with large doses able to produce diarrhea.
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