Renal blood flow, glomerular filtration rate, and tubular function are reduced in both preterm and term neonates. Therefore, newborns, especially those less than 34 weeks' gestation, require less frequent dosing intervals for many drugs. Aminoglycosides are administered every 8 hours in older children, every 12 hours in new-borns, and every 24 hours in extremely premature infants. The glomerular filtration rate of the term newborn is approximately 50% less than the adult level but reaches adult values by 1 year of age. Renal blood flow approaches adult values between ages 5 and 12 months. Tubular secretory functions mature at a slower rate than does glomerular filtration. Renal excretion of organic anions, such as penicillin, furosemide, and indomethacin, is very low in the newborn. Tubular secretion and reabsorption reach adult levels by 7 months of age. Renal elimination of drugs appears to play a greater role than does metabolism in newborns. Over the first year of life the infant develops a more adult-type excretory pattern.
Was this article helpful?
Learning About 10 Ways Fight Off Cancer Can Have Amazing Benefits For Your Life The Best Tips On How To Keep This Killer At Bay Discovering that you or a loved one has cancer can be utterly terrifying. All the same, once you comprehend the causes of cancer and learn how to reverse those causes, you or your loved one may have more than a fighting chance of beating out cancer.