Electrophysiological Actions

Quinidine's effect on the electrical properties of a particular cardiac tissue depends on the extent of parasympathetic innervation, the level of parasympa-thetic tone, and the dose. The anticholinergic actions of quinidine predominate at lower plasma concentrations. Later, when steady-state therapeutic plasma concentrations have been achieved, the drug's direct electro-physiological actions predominate. The direct and indirect electrophysiological actions are summarized in Table 16.2.

T ABLE 16.2 Cardiac Electrophysiological Effects of Class I Antiarrhythmic Drugs




S-A Node

A-V Node


Ventric Muscle

10 Ways To Fight Off Cancer

10 Ways To Fight Off Cancer

Learning About 10 Ways Fight Off Cancer Can Have Amazing Benefits For Your Life The Best Tips On How To Keep This Killer At Bay Discovering that you or a loved one has cancer can be utterly terrifying. All the same, once you comprehend the causes of cancer and learn how to reverse those causes, you or your loved one may have more than a fighting chance of beating out cancer.

Get My Free Ebook

Post a comment