Electrophysiological Actions

Quinidine's effect on the electrical properties of a particular cardiac tissue depends on the extent of parasympathetic innervation, the level of parasympa-thetic tone, and the dose. The anticholinergic actions of quinidine predominate at lower plasma concentrations. Later, when steady-state therapeutic plasma concentrations have been achieved, the drug's direct electro-physiological actions predominate. The direct and indirect electrophysiological actions are summarized in Table 16.2.

T ABLE 16.2 Cardiac Electrophysiological Effects of Class I Antiarrhythmic Drugs




S-A Node

A-V Node


Ventric Muscle

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