Electrophysiological Actions

Adenosine receptors are found on myocytes in the atria and sinoatrial and A-V nodes. Stimulation of these receptors acts via a G-protein signaling cascade to open an acetylcholine-sensitive outward potassium current. This leads to hyperpolarization of the resting membrane potential, a decrease in the slope of phase 4 spontaneous depolarization, and shortening of the action potential duration.

The effects on the A-V node may result in a conduction block and the termination of tachycardias that use the A-V node as a limb of a reentrant circuit. Adenosine does not affect the action potential of ventricular myocytes because the adenosine-stimulated potassium channel is absent in ventricular myocardium.

Peripheral Neuropathy Natural Treatment Options

Peripheral Neuropathy Natural Treatment Options

This guide will help millions of people understand this condition so that they can take control of their lives and make informed decisions. The ebook covers information on a vast number of different types of neuropathy. In addition, it will be a useful resource for their families, caregivers, and health care providers.

Get My Free Ebook


Post a comment