Electrocardiographic Changes

The electrocardiographic effects of moricizine include alterations in conduction velocity without an effect on the refractoriness of heart tissue. Moricizine enhances sinus node automaticity and prolongs sinoatrial and His-Purkinje intervals and the QRS. Moricizine prolongs ventricular conduction, thereby widening the QRS complex on the electrocardiogram. It has no significant effects on the QT interval.

The administration of moricizine is not associated with clinically significant hemodynamic effects.

fects requiring drug withdrawal include conduction defects, sinus pauses, junctional rhythm, and A-V block.

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