Drug Interactions

Serious hypertension can occur with concomitant administration of over-the-counter cough and cold medications containing sympathomimetic amines. When switching from a MAOI to another antidepressant, such as a SSRI, a drug-free period of 2 weeks is required to allow for the regeneration of tissue MAO and elimination of the MAOI. When switching from an antidepres-sant, such as an SSRI, to a MAOI, sufficient time should be allowed for the SSRI to be cleared from the body (at least 5 half-lives) before starting the MAOI. Special note should be taken of fluoxetine's long half-life, requiring at least 5 weeks after discontinuation of fluoxe-tine at a 20-mg dose and longer at higher doses, before initiation of MAOI therapy. Coadministration of a MAOI and an SSRI or venlafaxine can overstimulate the serotonin receptors in the brainstem and spinal cord (serotonin syndrome), which can be lethal. Serotonin syndrome consists of a constellation of psychiatric, neurological, and cardiovascular symptoms that may include confusion, elevated or dysphoric mood, tremor, myoclonus, incoordination, hyperthermia, and cardiovascular collapse.

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Blood Pressure Health

Blood Pressure Health

Your heart pumps blood throughout your body using a network of tubing called arteries and capillaries which return the blood back to your heart via your veins. Blood pressure is the force of the blood pushing against the walls of your arteries as your heart beats.Learn more...

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