Since allopurinol is metabolized by the hepatic microsomal drug-metabolizing enzymes, coadministration of drugs also metabolized by this system should be done with caution. Because allopurinol inhibits the oxidation of mercaptopurine and azathioprine, their individual administered doses must be decreased by as much as 75% when they are given together with allopurinol. Allopurinol may also increase the toxicity of other cytotoxic drugs (e.g., vidarabine). The actions of allopuri-nol are not antagonized by the coadministration of sal-icylates.
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