Drug Interactions

Antineoplastic drugs may participate in several types of drug interactions. Methotrexate, for example, is highly bound to serum albumin and can be displaced by sali-cylates, sulfonamides, phenothiazines, phenytoin, and other organic acids. The induction of hepatic drug-metabolizing enzymes by phenobarbital may alter the metabolism of cyclophosphamide to both active and inactive metabolites. Mercaptopurine metabolism is blocked by allopurinol, an occurrence that may result in lethal toxicity if the dosage of mercaptopurine is not reduced to one-fourth of the usual dosage. Methotrexate is secreted actively by the renal tubules, and its renal clearance may be delayed by salicylates.

Procarbazine exhibits an interesting interaction with ethanol, resulting in headaches, diaphoresis, and facial erythema; patients taking this drug should be forewarned to abstain from alcohol. Procarbazine is also a monoamine oxidase (MAO) inhibitor and may potentiate the effects of drugs that are substrates for this enzyme.

The biliary and renal excretion of some drugs (e.g., anthracyclines, vinca alkaloids, dactinomycin, etopo-side) by the P-glycoprotein multidrug transporter can be inhibited by other drugs that are also transported by P-glycoprotein.

Peripheral Neuropathy Natural Treatment Options

Peripheral Neuropathy Natural Treatment Options

This guide will help millions of people understand this condition so that they can take control of their lives and make informed decisions. The ebook covers information on a vast number of different types of neuropathy. In addition, it will be a useful resource for their families, caregivers, and health care providers.

Get My Free Ebook

Post a comment