Drug Interactions

Because of their multiple effects, antipsychotic drugs produce more important pharmacodynamic than phar-

macokinetic interactions. The action of other CNS depressants may be enhanced, and concurrent use of tri-cyclic antidepressants or other agents with anticholiner-gic activity may cause additive CNS dysfunction and peripheral anticholinergic effects. The hypotensive ef fects of an antipsychotic may be increased by diuretics, captopril, and other antihypertensive medications. Anti-psychotic agents are also susceptible to enhanced metabolism by inducers of microsomal mixed-function oxidases.

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