In the presence of phenytoin, the metabolism of disopy-ramide is increased (reducing its effective concentration) and the accumulation of its metabolites is also increased, thereby increasing the probability of anti-cholinergic adverse effects. Rifampin also stimulates the hepatic metabolism of disopyramide, reducing its plasma concentration.
Unlike quinidine, disopyramide does not increase the plasma concentration of digoxin in patients receiving a maintenance dose of the cardiac glycoside. Hypoglycemia has been reported with the use of disopyramide, particularly in conjunction with moderate or excessive alcohol intake.
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