Diuretic Response

During the peak effect of the loop diuretics, urine flow is greatly augmented, as is the excretion of Na+ and Cl", corresponding to as much as 20 to 30% of their filtered load. K+ loss also occurs as an indirect effect of the large Na+ load reaching the distal tubules and is 2 to 5 times above normal levels of K+ excretion. With low or moderately effective doses, these drugs do not appreciably affect HCO3" or H+ excretion.

Furosemide (Lasix), torsemide (Demadex), and bumetanide (Bumex) possess some carbonic anhydrase inhibiting activity (about one-tenth that of chloroth-iazide). This property may account for the increased bicarbonate and phosphate excretion seen after large doses of these diuretics. The elevated HCO3" loss probably indicates some proximal tubular effects for furosemide and bumetanide.

Peripheral Neuropathy Natural Treatment Options

Peripheral Neuropathy Natural Treatment Options

This guide will help millions of people understand this condition so that they can take control of their lives and make informed decisions. The ebook covers information on a vast number of different types of neuropathy. In addition, it will be a useful resource for their families, caregivers, and health care providers.

Get My Free Ebook


Post a comment