Once an agent is topically applied in the oral cavity, the free drug can act at the primary site (i.e., bacteria in the plaque), or it can be partitioned to compartments where the drug binds nonspecifically. These drug reservoirs include the enamel, dentin, and/or cementum of the tooth, the oral mucosa, the organic and inorganic components of plaque, and salivary proteins.

The fraction of the administered dose that is non-specifically bound to oral reservoirs is highly dependent on the drug's concentration and chemical nature and the amount of time it remains at the site. For example, a 1-minute rinse with 0.2% chlorhexidine will result in approximately 30% of the total amount dispensed being retained, whereas a 3-minute rinse with 0.1% sodium fluoride will result in less than 1% of the administered dose being found in the oral cavity after an hour. The ability of oral agents to bind to oral reservoirs nonspecifically and reversibly is an important quality for sustained release of drugs.

Was this article helpful?

0 0
10 Ways To Fight Off Cancer

10 Ways To Fight Off Cancer

Learning About 10 Ways Fight Off Cancer Can Have Amazing Benefits For Your Life The Best Tips On How To Keep This Killer At Bay Discovering that you or a loved one has cancer can be utterly terrifying. All the same, once you comprehend the causes of cancer and learn how to reverse those causes, you or your loved one may have more than a fighting chance of beating out cancer.

Get My Free Ebook

Post a comment