Digitalization

Digitalis remains notorious today for its very narrow dosage window for therapeutic efficacy without toxicity. A unique process, digitalization, for dosing digitalis (digoxin [Lanoxin]; digitoxin [Crystodigin]) has been widely accepted over the years as a means of minimizing toxicity. This process is to start patients on several repeated doses of digitalis over 24 to 36 hours before establishing a lower daily maintenance dose. Digitalis has become the mainstay of therapy for CHF despite its

L-Type Calcium Channel

Ca2+

Adenylate cyclase G-protein

P-Adrenergic Receptor a-Adrenergic Receptor

Angiotensin II Receptor

L-Type Calcium Channel

Ca2+

Adenylate cyclase G-protein

P-Adrenergic Receptor a-Adrenergic Receptor

Angiotensin II Receptor

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