Cyp3a4

<3

F+;FPM;H?;R?

"Average values for fed adult patients following multiple oral doses. 'Unchanged drug.

cMajor isoform responsible for drug metabolism. ^Capsule formulation.

F+, food (high fat meal) increases absorption;F—, food decreases absorption;FPM, extensive first-pass metabolism;H, dosage adjustment is necessary in patients with hepatic impairment;(h), dosage adjustment may be required in patients with hepatic impairment;H?, dosage adjustment in patients with hepatic impairment has not been studied;R, dosage adjustment is necessary in patients with renal impairment;R?, dosage adjustment in patients with renal impairment has not been studied.

TABLE 51.6 interactions Among Protease inhibitors

Drug

Increases Plasma AUC of

Decreases Plasma AUC of

Plasma AUC Increased by

Plasma AUC Decreased by

Amprenavir

Nelfinavir

Indinavir

Indinavir Nelfinavir Ritonavir

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