Corticosteroids

A major breakthrough in asthma therapy was the introduction in the 1970s of aerosol corticosteroids. These agents (Table 39.3) maintain much of the impressive therapeutic efficacy of parenteral and oral cortico-steroids, but by virtue of their local administration and markedly reduced systemic absorption, they are associated with a greatly reduced incidence and severity of side effects. The success of inhaled steroids has led to a substantial reduction in the use of systemic cortico-steroids. Inhaled corticosteroids, along with ยก2-adreno-ceptor agonists, are front-line therapy of chronic asthma.

TABLE 39.3 Corticosteroids Used in Asthma

Class

Agent

Trade Name

Route

Oral corticosteroids

Prednisone

Deltasone

Oral

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