One of the few absolute contraindications for quinidine is complete A-V block with an A-V pacemaker or id-ioventricular pacemaker; this may be suppressed by quinidine, leading to cardiac arrest.

Persons with congenital QT prolongation may develop torsades de pointes tachyarrhythmia and should not be exposed to quinidine.

Owing to the negative inotropic action of quinidine, it is contraindicated in congestive heart failure and hypotension.

Digitalis intoxication and hyperkalemia can accentuate the depression of conduction caused by quinidine.

Myasthenia gravis can be aggravated severely by quinidine's actions at the neuromuscular junction.

The use of quinidine and quinine should be avoided in patients who previously showed evidence of quini-dine-induced thrombocytopenia.

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