Contraindications

Propafenone is contraindicated in the presence of severe or uncontrolled congestive heart failure; cardio-genic shock; sinoatrial, A-V, and intraventricular disorders of conduction; and sinus node dysfunction, such as sick sinus syndrome. Other contraindications include severe bradycardia, hypotension, obstructive pulmonary disease, and hepatic and renal failure. Because of its weak p-blocking action, propafenone may cause possible dose-related bronchospasm. This problem is greatest in patients who are slow metabolizers.

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