Verapamil must be used with extreme caution or not at all in patients who are receiving ^-adrenoceptor blocking agents. Normally, the negative chronotropic effect of verapamil will in part be overcome by an increase in reflex sympathetic tone. The latter is be prevented by simultaneous administration of a (3-adrenoceptor blocking agent, which exaggerates the depressant effects of verapamil on heart rate, A-V node conduction, and myocardial contractility. The use of verapamil in children less than 1 year of age is controversial.

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The Prevention and Treatment of Headaches

The Prevention and Treatment of Headaches

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