Contraindications and Drug Interactions

Co-morbid factors that increase the risk of NSAID-induced GI bleeding include history of ulcer disease, advanced age, poor health status, treatment with certain drugs (discussed later), long duration of NSAID therapy, smoking, and heavy alcohol use. Because of their renal effects, NSAIDs must be used with caution in

TABLE 36.2 Adverse Effects of NSAIDs - Relationship to Prostaglandin Synthesis Inhibition and Cyclooxygenase Isoforms

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The Prevention and Treatment of Headaches

The Prevention and Treatment of Headaches

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