The aminoquinolines accumulate in lung, kidney, and liver; thus, any preexisting pathology in these tissues contraindicates their use. Similarly, any ocular pathol ogy precludes their use. Psoriasis and porphyria are frequently exacerbated by the administration of the aminoquinolines.
Aminoquinolines can increase plasma concentrations of penicillamine, hence the potential for serious hematological or renal toxicity. Similarly, aminoquinolines can increase digoxin levels. Gold and an amino-quinoline probably should not be administered concurrently because of the propensity of each to produce dermatitis.
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