Contraindications and Drug Interactions

Gold compounds are contraindicated for use in patients with systemic lupus erythematosus, Sjogren's syndrome, severe debilitation, or uncontrolled congestive heart failure or hypertension. Caution must be used in administering gold compounds to individuals who have conditions that might increase their susceptibility to gold toxicity: blood dyscrasias, immunosuppression, renal disease, hepatic disease, skin diseases, or inflammatory bowel disease. Animal studies have shown adverse effects on reproduction; gold compounds may distribute to breast milk and are therefore contraindicated for women who are breast-feeding.

Gold should be used cautiously in patients receiving drugs that can also cause nephrotoxicity. Interactions between gold compounds and penicillamine may result in severe hematological and renal side effects.

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