Clonidine (Catapres) is effective orally and is used primarily for the treatment of moderate hypertension. It is structurally related to the a-adrenoceptor antagonists phentolamine and tolazoline. Clonidine, however, is not an a-blocker, but is actually an a-agonist. Its antihyper-tensive effectiveness appeared paradoxical until it was recognized that clonidine activated central a2-receptors, thus reducing sympathetic outflow to the periphery.
Guanabenz (Wytensin) and guanfacine (Tenex) are two drugs with considerable structural similarity to clonidine. These agents also are central a2-agonists and exhibit an antihypertensive profile similar to that of clonidine.
Was this article helpful?
Do You Suffer From High Blood Pressure? Do You Feel Like This Silent Killer Might Be Stalking You? Have you been diagnosed or pre-hypertension and hypertension? Then JOIN THE CROWD Nearly 1 in 3 adults in the United States suffer from High Blood Pressure and only 1 in 3 adults are actually aware that they have it.