Clonidine and Related Drugs

Clonidine (Catapres) is effective orally and is used primarily for the treatment of moderate hypertension. It is structurally related to the a-adrenoceptor antagonists phentolamine and tolazoline. Clonidine, however, is not an a-blocker, but is actually an a-agonist. Its antihyper-tensive effectiveness appeared paradoxical until it was recognized that clonidine activated central a2-receptors, thus reducing sympathetic outflow to the periphery.

Guanabenz (Wytensin) and guanfacine (Tenex) are two drugs with considerable structural similarity to clonidine. These agents also are central a2-agonists and exhibit an antihypertensive profile similar to that of clonidine.

Blood Pressure Health

Blood Pressure Health

Your heart pumps blood throughout your body using a network of tubing called arteries and capillaries which return the blood back to your heart via your veins. Blood pressure is the force of the blood pushing against the walls of your arteries as your heart beats.Learn more...

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