Foscarnet is indicated for the treatment of CMV retinitis in AIDS patients. Its effectiveness is comparable to that of ganciclovir; these drugs are synergistic when given to counteract refractory retinitis. A decreased incidence of Kaposi's sarcoma has been observed in AIDS patients who have undergone foscarnet therapy.
Foscarnet is approved for the treatment of acyclovir-resistant mucocutaneous HSV infections in immuno-compromised individuals. A clinical study indicated that it is more effective than vidarabine. Foscarnet has also been used for the treatment of acyclovir-resistant VZV and nonretinitis forms of CMV infection, although its efficacy is not so well established.
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