Clinical Uses of AT1 Receptor Antagonists

Angiotensin type 1 receptor antagonists are effective as monotherapy in the treatment of hypertension.While all of the AT1 receptor antagonists are effective in the treatment of hypertension, several comparative studies have suggested that longer-acting AT1 receptor antagonists, such as irbesartan, candesartan, and telmisartan, may be more effective than the shorter-acting antagonists at providing 24-hour control of blood pressure. In large-scale clinical trials, AT1 receptor antagonists did not exhibit a clear advantage over ACE inhibitors in reducing morbidity and mortality from congestive heart failure.Therefore, the use of ATI receptor antagonists in the treatment of congestive heart failure is generally restricted to patients who do not tolerate ACE inhibitors.

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