Labetalol is useful for the chronic treatment of primary hypertension. It can be used alone but is more often employed in combination with other antihypertensive agents. Labetalol also has been used intravenously for the treatment of hypertensive emergencies. Like conventional p-blockers, labetalol may be useful for patients with coexisting hypertension and anginal pain due to ischemia. It is also being investigated as a possible therapeutic modality for ischemic heart disease, even in the absence of hypertension. The benefit derives from its p-blocking activity, which decreases cardiac work, and from its ability to decrease afterload by virtue of its a-blocking activity.
Labetalol, because it possesses both a- and p-blocking activity, is useful for the preoperative management of patients with a pheochromocytoma.
Was this article helpful?
Your heart pumps blood throughout your body using a network of tubing called arteries and capillaries which return the blood back to your heart via your veins. Blood pressure is the force of the blood pushing against the walls of your arteries as your heart beats.Learn more...