Classification Of Blocking Drugs

An a-receptor is one that mediates responses for which the adrenomimetic order of potency is epinephrine greater than or equal to norepinephrine greater than iso-proterenol, and that is susceptible to blockade by phen-tolamine and phenoxybenzamine. It follows from this definition that phentolamine and phenoxybenzamine are called a-adrenoceptor antagonists or a-blocking agents. A p-receptor mediates responses for which the adreno-mimetic order of potency is isoproterenol greater than epinephrine greater than or equal to norepinephrine, and this receptor is susceptible to blockade by propra-nolol. Propranolol is, therefore, called a p-adrenoceptor antagonist or p-blocking agent.

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