Chlorambucil

Chlorambucil (Leukeran) is an aromatic nitrogen mustard that is intermediate in chemical reactivity between mechlorethamine and melphalan. Its mechanisms of action and range of antitumor activity are similar to theirs. It is well absorbed orally, but detailed information concerning its metabolic fate in humans is lacking.

Chlorambucil is used primarily as daily palliative therapy for chronic lymphocytic leukemia, Waldenstrom's macroglobulinemia, myeloma, and other lymphomas.

Bone marrow toxicity is the major side effect of chlorambucil. Nausea is uncommon or mild, and hair loss does not occur. Chlorambucil shares the immuno-suppressive, teratogenic, and carcinogenic properties of the nitrogen mustards.

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