Chemistry

The adrenomimetic drugs can be divided into two major groups on the basis of their chemical structure: the catecholamines and the noncatecholamines. The cate-cholamines include norepinephrine, epinephrine, and dopamine, all of which are naturally occurring, and several synthetic substances, the most important of which is isoproterenol (isopropyl norepinephrine). The skele-

Many adrenomimetic drugs produce responses by interacting with the adrenoceptors on sympathetic effector cells. An examination of Table 9.1 reveals that sympathetic effectors have activity at a0 a2-, or (32-adrenoreceptors or in some cases, combinations of these adrenoceptors. Adrenomimetic drugs vary in their affinities for each subgroup of adrenoceptors. Some, like epi-nephrine, have a high affinity for all of the adrenocep-

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