Epinephrine, in therapeutic doses, mildly stimulates the CNS. The most noticeable features of this stimulation are apprehension, restlessness, and increased respiration. In therapeutic doses both isoproterenol and nor-epinephrine also have minor CNS stimulant properties. Since these compounds do not easily cross the blood-brain barrier, the mechanism of their stimulatory effects is not clear. It is likely that the stimulating effects are primarily, if not entirely, due to actions in the periphery that alter the neural input to the CNS.
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