Cellular Uptake and Intracellular Binding of T3 to Nuclear Thyroid Hormone Receptors

Free T4 and T3 can enter cells by carrier-mediated facilitated diffusion or active transport. After gaining access to the cell interior, T4 may undergo 5'-monodeiodina-tion to yield T3. The T3 thus mixes with T3 entering the cell from the plasma and binds to nuclear TRs. The specific 5'-monodeiodinase enzyme and the level of activity vary from tissue to tissue, as does the contribution of plasma T4 to nuclear TR-bound T3.

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