Basic Pharmacology

The general pharmacological actions of adrenomimet-ics are described in detail in Chapter 10. The principal pharmacological effects that may be observed in humans treated for bronchospasm are bronchodilation, tachycardia, anxiety, and tremor. Stimulating (32-adreno-ceptors produces all of these effects either directly or indirectly.

Epinephrine activates both a- and (3-adrenoceptors, whereas isoproterenol is selective for p-adrenoceptors but does not discriminate between p1- and ^-adrenoceptors. Much-improved selectivity is offered by agents such as albuterol, terbutaline, and salmeterol. These compounds have a higher affinity for p2- adrenoceptors, the predominant subtype in the airway, than for p1-adrenoceptors. Other p2-selective adrenomimetics used as bronchodilators are bitolterol (Tornalate) and pir-

Coping with Asthma

Coping with Asthma

If you suffer with asthma, you will no doubt be familiar with the uncomfortable sensations as your bronchial tubes begin to narrow and your muscles around them start to tighten. A sticky mucus known as phlegm begins to produce and increase within your bronchial tubes and you begin to wheeze, cough and struggle to breathe.

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