The clinically important a-blockers fall primarily into three chemical groups: the haloalkylamines ( e.g., phe-
noxybenzamine), the imidazolines (e.g., phentolamine), and the quinazoline derivatives (e.g., prazosin). Of these three classes of a-adrenoceptor antagonists, the quina-zoline compounds are of greatest clinical utility and are emphasized in this chapter. The use of the haloalky-lamines and imidazolines has diminished in recent years because they lack selectivity for a1- and a2-receptors. Comparative information concerning the three chemical classes of antagonists is presented in Table 11.1
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