Antifungal Spectrum

Amphotericin B is used to treat systemic disseminated fungal infections caused by Candida spp., Cryptococcus neoformans, and the invasive dimorphic fungi (Aspergillus spp., Histoplasma capsulatum, Coccidioides immi-tis, Blastomyces dermatitidis, and Sporothrix schenckii). Intravenous amphotericin B remains the treatment of choice for serious invasive fungal infections unresponsive to other agents.

The development of resistance during amphotericin B therapy is rarely clinically significant but has been reported; relative resistance expressed through alterations in membrane ergosterols has resulted in fungal isolates with reduced growth rates and reduced virulence. Infections with organisms intrinsically resistant to amphotericin B, such as Candidia lusitaniae and Pseudallescheria boydii, are uncommon but may be increasing in frequency.

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