The sulfonamides are broad-spectrum antimicrobials that are effective against gram-positive and some gramnegative organisms of the Enterobacteriaceae. There is good activity against Escherichia coli, moderate activity against Proteus mirabilis and Enterobacter spp.; poor activity against indole-positive Proteus and Klebsiella spp., and no inhibitory activity against Pseudomonas aeruginosa and Serratia spp. They are also effective against Chlamydia spp., but superior drugs are now
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