The tetracyclines display broad-spectrum activity and are effective against both gram-positive and gram-negative bacteria, including Rickettsia, Coxiella, Mycoplasma, and Chlamydia spp.. Tetracycline resistance has increased among pneumococci and gonococci, which limits their use in the treatment of infections caused by these organisms.
Although several congeners of the tetracyclines are available, they all have a similar spectrum of in vitro activity. Minocycline is somewhat more active and oxytet-racycline and tetracycline are somewhat less active than other members of this group.
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